59 Series A biotech investors in the US

Top 5 Series A biotech investors in the US, ranked by recent fund activity

Among firms with a published profile and a dated fund or deal in the last 24 months. The rule: Activity score out of 100: recency of the latest fund filing or dated deal (30: full marks within 3 months, then stepping down at 6, 12 and 24 months), share of the observed portfolio in this sector (20; half of that when the sector is stated only), stage focus (15: all of it when Series A is the only stage the firm states, split evenly when it states more), stated focus on the US (15: full marks when the firm names the US as where it invests, half when it says global), size of the fund on file on a log scale (12) and completeness of the public record (8). Stage and regional focus are our research, not an SEC figure. It is a measure of activity and fit, not of quality or returns. The same rule orders the whole list; it is repeated in the method box.

1. Madrona

   Type: VC firm · HQ: Seattle, WA · Stages: Pre-seed, Seed, Series A, Series B, Growth · Focus: Biotech, AI, Consumer, Deep Tech · Latest activity: New deal, Oct 2026 · Fund size on file: $490M (SEC Form D, 2025)

   Dated new deal in Oct 2026; $490M fund on file (SEC Form D, 2025); states biotech and life sciences as a focus; backs pre-seed, seed, Series A; names the US as where it invests; 8 named decision-makers on file.

2. Bison Ventures

   Type: VC firm · HQ: San Francisco, CA · Stages: Pre-seed, Seed, Series A, Series B · Focus: Biotech, AI, Healthtech, Energy · Latest activity: New fund, Oct 2026 · Fund size on file: $160M (SEC Form D, 2025)

   Latest fund filing dated Oct 2026; $160M fund on file (SEC Form D, 2025); 21% of its observed portfolio is biotech and life sciences; backs pre-seed, seed, Series A; names the US as where it invests; 2 named decision-makers on file.

3. Felicis

   Type: VC firm · HQ: Menlo Park, CA · Stages: Seed, Series A · Focus: Biotech, AI, Developer Tools, Healthtech · Latest activity: New deal, Oct 2026 · Fund size on file: $900M (SEC Form D, 2025)

   Dated new deal in Oct 2026; $900M fund on file (SEC Form D, 2025); states biotech and life sciences as a focus; backs seed, Series A; 8 named decision-makers on file.

4. DeepWork Capital

   Type: VC firm · HQ: Orlando, FL · Stages: Seed, Series A · Focus: Biotech, Healthtech, Fintech, AI · Latest activity: New deal, Jun 2026 · Fund size on file: $100M (SEC Form D, 2023)

   Dated new deal in Jun 2026; $100M fund on file (SEC Form D, 2023); 31% of its observed portfolio is biotech and life sciences; backs seed, Series A; names the US as where it invests; 8 named decision-makers on file.

5. Union Square Ventures

   Type: VC firm · HQ: New York, NY · Stages: Seed, Series A · Focus: Biotech, AI, Generalist, Robotics · Latest activity: New deal, Oct 2026 · Fund size on file: $3M (SEC Form D, 2026)

   Dated new deal in Oct 2026; $3M fund on file (SEC Form D, 2026); states biotech and life sciences as a focus; backs seed, Series A; names the US as where it invests; 8 named decision-makers on file.

First 25 of 59 Series A biotech investors in the US

You are seeing 25 of 59. The full list adds 34 more investors and 333 named decision-makers.

How these 59 break down

Questions

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