---
title: "59 Series A Biotech Investors in the US (Nov 2026)"
last_updated: "2026-11-06"
rows: "59"
free_rows: "25"
source: "SEC filings"
canonical: "https://theinvestordatabase.com/lists/series-a-biotech-investors-us/"
---

# 59 Series A biotech investors in the US

We list 59 Series A biotech investors in the US as of November 2026: each has an SEC filing on file, and the list was last checked on 6 Nov 2026. The cities with the most head offices on this list are New York (6), San Francisco (5) and Menlo Park (4).

- 59 investors
- 37 with a fund filing or dated deal in the last 12 months
- $90M median fund size on file (SEC Form D, 39 firms)
- 333 named decision-makers on file

## First 25 of 59 Series A biotech investors in the US

| Investor | Type | HQ | Stages (our research) | Focus (our research) | Latest fund or deal | Fund size | Checked | Profile |
|---|---|---|---|---|---|---|---|---|
| Madrona | VC firm | Seattle, WA | Pre-seed, Seed, Series A, Series B, Growth | Biotech, AI, Consumer, Deep Tech | New deal, Oct 2026 | $490M (SEC Form D, 2025) | 2026-11-05 | https://theinvestordatabase.com/investors/madrona/ |
| Bison Ventures | VC firm | San Francisco, CA | Pre-seed, Seed, Series A, Series B | Biotech, AI, Healthtech, Energy | New fund, Oct 2026 | $160M (SEC Form D, 2025) | 2026-11-04 | https://theinvestordatabase.com/investors/bison-ventures/ |
| Felicis | VC firm | Menlo Park, CA | Seed, Series A | Biotech, AI, Developer Tools, Healthtech | New deal, Oct 2026 | $900M (SEC Form D, 2025) | 2026-11-05 | https://theinvestordatabase.com/investors/felicis/ |
| DeepWork Capital | VC firm | Orlando, FL | Seed, Series A | Biotech, Healthtech, Fintech, AI | New deal, Jun 2026 | $100M (SEC Form D, 2023) | 2026-11-05 | https://theinvestordatabase.com/investors/deepwork-capital/ |
| Union Square Ventures | VC firm | New York, NY | Seed, Series A | Biotech, AI, Generalist, Robotics | New deal, Oct 2026 | $3M (SEC Form D, 2026) | 2026-11-04 | https://theinvestordatabase.com/investors/union-square-ventures/ |
| Cybernetix Ventures | VC firm | Boston, MA | Pre-seed, Seed, Series A | Biotech, Robotics, Industrial Tech, Logistics | New fund, Aug 2026 | $100M (SEC Form D, 2025) | 2026-11-04 | https://theinvestordatabase.com/investors/cybernetix-ventures/ |
| How Women Invest | VC firm | Oakland, CA | Pre-seed, Seed, Series A, Series B | Biotech, Healthtech, AI, B2B | New fund, Sep 2026 | $12M (SEC Form D, 2026) | 2026-11-04 | https://theinvestordatabase.com/investors/how-women-invest/ |
| Arboretum Ventures | VC firm | Ann Arbor, MI | Series A, Series B | Biotech, Healthtech, Medtech | Portfolio news, Mar 2026 | $250M (SEC Form D, 2022) | 2026-11-05 | https://theinvestordatabase.com/investors/arboretum-ventures/ |
| SHD Partners | VC firm | Dallas, TX | Seed, Series A | Biotech, Healthtech, Medtech | Portfolio news, Nov 2026 | $61M (SEC Form ADV) | 2026-11-05 | https://theinvestordatabase.com/investors/shd-partners/ |
| Draper Associates | VC firm | San Mateo, CA | Pre-seed, Seed, Series A | Biotech, AI, Fintech, Healthtech | New fund, Oct 2026 | $301M (SEC Form D, 2025) | 2026-11-04 | https://theinvestordatabase.com/investors/draper-associates/ |
| Andreessen Horowitz (a16z) | VC firm | Menlo Park, CA | Seed, Series A, Series B, Growth | Biotech, AI, Defense Tech, Healthtech | New fund, Aug 2026 |  | 2026-11-04 | https://theinvestordatabase.com/investors/andreessen-horowitz-a16z/ |
| Magnetic Ventures | VC firm | Miami Beach, FL | Seed, Series A | Biotech, AI, Healthtech, Edtech | New fund, Mar 2026 | $100M (SEC Form D, 2022) | 2026-11-04 | https://theinvestordatabase.com/investors/magnetic-ventures/ |
| First Bight Ventures | VC firm | Houston, TX | Seed, Series A | Biotech, Climate Tech, Healthtech, Industrial Tech | New fund, Mar 2026 | $80M (SEC Form D, 2022) | 2026-11-04 | https://theinvestordatabase.com/investors/first-bight-ventures/ |
| Kapor Capital | VC firm | Oakland, CA | Pre-seed, Seed, Series A | Biotech, Edtech, Fintech, Healthtech | New deal, Jun 2026 | $125M (SEC Form D, 2021) | 2026-11-05 | https://theinvestordatabase.com/investors/kapor-capital/ |
| Cornucopian Capital | VC firm | Montclair, NJ | Pre-seed, Seed, Series A, Series B | Biotech, Healthtech, AI, Medtech | New fund, Aug 2026 | $12M (SEC Form D, 2024) | 2026-11-04 | https://theinvestordatabase.com/investors/cornucopian-capital/ |
| MGP Venture Fund III | VC firm | Nashville, TN | Series A | Biotech, Healthtech, Agritech, Energy | Portfolio news, Jul 2025 | $150M (SEC Form D, 2021) | 2026-11-05 | https://theinvestordatabase.com/investors/mgp-venture-fund-iii/ |
| Calculus VC | VC firm | Foster City, CA | Series A, Series B | Biotech, AI, Deep Tech, Healthtech | New deal, Aug 2026 | $1M (SEC Form D, 2025) | 2026-11-04 | https://theinvestordatabase.com/investors/calculus-vc/ |
| B Capital | VC firm | Manhattan Beach, CA | Seed, Series A, Series B, Growth | Biotech, AI, Fintech, Healthtech | New fund, Jul 2025 | $307M (SEC Form D, 2023) | 2026-11-04 | https://theinvestordatabase.com/investors/b-capital/ |
| SVG Ventures | VC firm | Los Gatso, CA | Seed, Series A | Biotech, Agritech, Food and Beverage, Climate Tech | New deal, Nov 2025 |  | 2026-11-05 | https://theinvestordatabase.com/investors/svg-ventures/ |
| Cultivation Capital | VC firm | St. Louis, MO | Seed, Series A, Series B | Biotech, Healthtech, SaaS, Agritech | New fund, Sep 2026 | $100M (SEC Form D, 2022) | 2026-11-04 | https://theinvestordatabase.com/investors/cultivation-capital/ |
| Antler | Accelerator | New York, NY | Pre-seed, Seed, Series A, Series B, Growth | Biotech, AI, Healthtech, Consumer | New deal, Aug 2026 | $90M (SEC Form D, 2023) | 2026-11-04 | https://theinvestordatabase.com/investors/antler/ |
| OMX Ventures | VC firm | Lincolnshire, IL | Seed, Series A | Biotech, Healthtech, AI, Medtech | Portfolio news, Sep 2025 | $253M (SEC Form ADV) | 2026-11-05 | https://theinvestordatabase.com/investors/omx-ventures/ |
| Overlap Holdings | VC firm | Hicksville, NY | Seed, Series A, Series B | Biotech, AI, Energy, Climate Tech | New fund, Oct 2026 | $16M (SEC Form D, 2023) | 2026-11-04 | https://theinvestordatabase.com/investors/overlap-holdings/ |
| Cerberus Ventures | VC firm | New York, NY | Pre-seed, Seed, Series A, Series B | Biotech, AI, Industrial Tech, Quantum | New fund, Jun 2026 | $75M (SEC Form D, 2024) | 2026-11-04 | https://theinvestordatabase.com/investors/cerberus-ventures/ |
| Apple Tree Venture | VC firm | New York, NY | Pre-seed, Seed, Series A, Series B, Growth | Biotech, Healthtech | Portfolio news, Sep 2025 | $3.5B (SEC Form ADV) | 2026-11-05 | https://theinvestordatabase.com/investors/apple-tree-venture/ |

You are seeing 25 of 59. The full list adds 34 more investors and 333 named decision-makers.

Get all 59 investors and 333 named contacts, $49, one-time: https://theinvestordatabase.com/buy/list/series-a-biotech-investors-us
This page: https://theinvestordatabase.com/lists/series-a-biotech-investors-us/

## Method and limits
- Source: All 59 rows carry an SEC filing (Form D or Form ADV). All 59 have a website we checked. Filing date and fund size are SEC data where a filing exists. Stage, sector and check size are our research.
- Inclusion rule: Organizations that back startups. Individuals, buyout funds and firms we found to be inactive are left out. Sector: the firm states biotech and life sciences as a focus on its own site, or we observed it in the firm's portfolio. Stage: the firm states that it invests at Series A.
- Order: Activity score out of 100: recency of the latest fund filing or dated deal (30: full marks within 3 months, then stepping down at 6, 12 and 24 months), share of the observed portfolio in this sector (20; half of that when the sector is stated only), stage focus (15: all of it when Series A is the only stage the firm states, split evenly when it states more), stated focus on the US (15: full marks when the firm names the US as where it invests, half when it says global), size of the fund on file on a log scale (12) and completeness of the public record (8). Stage and regional focus are our research, not an SEC figure. It is a measure of activity and fit, not of quality or returns.
- Fill rates: Of 59 rows: stage 59, sector 59, fund size 51, website 59. In the paid file: named decision-makers on 57 rows, firm email on 17, LinkedIn page on 33, check size on 6.

## Questions
### How many Series A biotech investors in the US are there?
We list 59 as of November 2026. 37 of the 59 have a fund filing or a dated deal in the last 12 months. The cities with the most are New York (6), San Francisco (5) and Menlo Park (4).

### Which Series A biotech investors in the US raised a new fund in the last 12 months?
21 of the 59 have a fund filing dated in the last 12 months. The most recent on this list are Draper Associates (Oct 2026), Bison Ventures (Oct 2026) and Overlap Holdings (Oct 2026).

### What is the typical fund size of Series A biotech investors in the US?
The median fund size on file for this list is $90M, across the 39 firms with a size on an SEC Form D. The fund on file is each firm's main fund, which is not always its newest. The other 20 do not disclose a size there.

### How do I contact Series A biotech investors in the US?
The paid file holds 333 named decision-makers across 57 of these 59 and a firm email for 17. We publish the address a firm lists itself, never a personal email. Each free row links to a profile with the firm's website.

### Where does the data on Series A biotech investors in the US come from?
All 59 rows have an SEC filing on file (Form D or Form ADV). Filing date and fund size come from the filing. Stage, sector and check size are our research. Rows on this list were last checked on 6 Nov 2026 at the latest. The whole file is re-verified twice a year.