18 venture capital firms in Missouri
We list 18 venture capital firms in Missouri as of November 2026: each has an SEC filing on file, and the list was last checked on 5 Nov 2026. The cities with the most head offices on this list are St. Louis (10), Kansas City (5) and Clayton (1).
Top 6 venture capital firms in Missouri, ranked by recent fund activity
Among firms with a published profile and a dated fund or deal in the last 24 months. The rule: Activity score out of 100: recency of the latest fund filing or dated deal (50: full marks within 3 months, then stepping down at 6, 12 and 24 months), size of the fund on file on a log scale (35) and completeness of the public record (15). It is a measure of activity and fit, not of quality or returns. The same rule orders the whole list; it is repeated in the method box.
SixThirty Ventures, LLC
Type: VC firm · HQ: Clayton, MO · Stages: Seed, Series A · Focus: Fintech, AI, Healthtech, Insurtech · Latest activity: New deal, Sep 2026 · Private fund assets: $134M (SEC Form ADV)
Dated new deal in Sep 2026; $134M on file (SEC Form ADV); backs seed, Series A; 8 named decision-makers on file.
Flyover Capital
Type: VC firm · HQ: Kansas City, MO · Stages: Seed, Series A · Focus: AI, Fintech, Healthtech, SaaS · Latest activity: New fund, Oct 2026 · Fund size on file: $75M (SEC Form D, 2026)
Latest fund filing dated Oct 2026; $75M fund on file (SEC Form D, 2026); backs seed, Series A; 8 named decision-makers on file.
Cultivation Capital
Type: VC firm · HQ: St. Louis, MO · Stages: Seed, Series A, Series B · Focus: Healthtech, Biotech, SaaS, Agritech · Latest activity: New fund, Sep 2026 · Fund size on file: $100M (SEC Form D, 2022)
Latest fund filing dated Sep 2026; $100M fund on file (SEC Form D, 2022); backs seed, Series A, Series B; 8 named decision-makers on file.
Redbud VC
Type: VC firm · HQ: Columbia, MO · Stages: Pre-seed · Focus: Healthtech, Agritech, AI, Climate Tech · Latest activity: New fund, Sep 2026 · Fund size on file: $25M (SEC Form D, 2025)
Latest fund filing dated Sep 2026; $25M fund on file (SEC Form D, 2025); backs pre-seed; 8 named decision-makers on file.
iSelect Fund
Type: VC firm · HQ: St. Louis, MO · Focus: Healthtech, Agritech, Food and Beverage, Biotech · Latest activity: New fund, Dec 2024 · Fund size on file: $97M (SEC Form D, 2024)
Latest fund filing dated Dec 2024; $97M fund on file (SEC Form D, 2024); 8 named decision-makers on file.
Stakehouse
Type: VC firm · HQ: St. Louis, MO · Stages: Pre-seed · Focus: Edtech · Latest activity: New fund, Aug 2025 · Fund size on file: $30M (SEC Form D, 2025)
Latest fund filing dated Aug 2025; $30M fund on file (SEC Form D, 2025); backs pre-seed; 2 named decision-makers on file.
First 10 of 18 venture capital firms in Missouri
| Investor | Type | HQ | Stagesour research | Focusour research | Latest fund or deal | Fund sizeas filed or stated | Checked | Contacts |
|---|---|---|---|---|---|---|---|---|
| SixThirty Ventures, LLC | VC firm | Clayton, MO | Seed, Series A | Fintech, AI, Healthtech, Insurtech | New deal, Sep 2026 | $134M (SEC Form ADV) | 5 Nov 2026 | 8 names, firm email · Unlock |
| Flyover Capital | VC firm | Kansas City, MO | Seed, Series A | AI, Fintech, Healthtech, SaaS | New fund, Oct 2026 | $75M (SEC Form D, 2026) | 4 Nov 2026 | 8 names, firm email · Unlock |
| Cultivation Capital | VC firm | St. Louis, MO | Seed, Series A, Series B | Healthtech, Biotech, SaaS, Agritech | New fund, Sep 2026 | $100M (SEC Form D, 2022) | 4 Nov 2026 | 8 names · Unlock |
| Redbud VC | VC firm | Columbia, MO | Pre-seed | Healthtech, Agritech, AI, Climate Tech | New fund, Sep 2026 | $25M (SEC Form D, 2025) | 4 Nov 2026 | 8 names · Unlock |
| iSelect Fund | VC firm | St. Louis, MO | Healthtech, Agritech, Food and Beverage, Biotech | New fund, Dec 2024 | $97M (SEC Form D, 2024) | 5 Nov 2026 | 8 names · Unlock | |
| Ascension Ventures | Corporate VC | St. Louis, MO | Growth | Healthtech, Medtech, Biotech | $475M (SEC Form ADV) | 5 Nov 2026 | 8 names, firm email · Unlock | |
| Stakehouse | VC firm | St. Louis, MO | Pre-seed | Edtech | New fund, Aug 2025 | $30M (SEC Form D, 2025) | 4 Nov 2026 | 2 names · Unlock |
| KCRise Fund | VC firm | Kansas City, MO | Seed | AI, Healthtech, Future of Work, Edtech | New deal, Dec 2023 | $42M (SEC Form D, 2020) | 5 Nov 2026 | 4 names · Unlock |
| Abstraction Capital | VC firm | Kansas City, MO | Pre-seed, Seed | AI, Developer Tools, SaaS, Data | New fund, Jun 2024 | $20M (SEC Form D, 2020) | 5 Nov 2026 | 1 name, firm email · Unlock |
| GX Expedition | VC firm | St. Louis, MO | New fund, May 2026 | $50M (SEC Form D, 2026) | 4 Nov 2026 | 1 name · Unlock |
You are seeing 10 of 18. The full list adds 8 more firms and 59 named decision-makers.
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How these 18 break down
By city
| City | On this list | Share |
|---|---|---|
| St. Louis | 10 | 56% |
| Kansas City | 5 | 28% |
By stage
| Stage | On this list | Share |
|---|---|---|
| Pre-Seed | 3 | 17% |
| Seed | 5 | 28% |
| Series A | 3 | 17% |
Stage is our research. A firm can back more than one stage.
By sector
| Sector | On this list | Share |
|---|---|---|
| AI | 7 | 39% |
| Healthtech | 7 | 39% |
| SaaS | 6 | 33% |
| Fintech | 3 | 17% |
| Biotech | 3 | 17% |
| Agritech | 3 | 17% |
| Medtech | 3 | 17% |
| Climate Tech | 2 | 11% |
| Future of Work | 2 | 11% |
| Edtech | 2 | 11% |
Sector is our research. A firm can carry more than one sector.
By type
| Type | On this list | Share |
|---|---|---|
| VC firm | 17 | 94% |
| Corporate VC | 1 | 6% |
Method and limits
- Source
- All 18 rows carry an SEC filing (Form D or Form ADV). 9 of the 18 have a website we checked; the other 9 rest on the filing or register entry alone. Filing date and fund size are SEC data where a filing exists. Stage, sector and check size are our research.
- Inclusion rule
- Organizations that back startups. Individuals, buyout funds and firms we found to be inactive are left out. This list holds VC firms, fund managers and corporate venture arms; accelerators and angel networks are in their own lists. Place: head office in Missouri.
- Order
- Firms with a published profile come first. Activity score out of 100: recency of the latest fund filing or dated deal (50: full marks within 3 months, then stepping down at 6, 12 and 24 months), size of the fund on file on a log scale (35) and completeness of the public record (15). It is a measure of activity and fit, not of quality or returns.
- Last refreshed
- November 2026. Rows on this list were checked between 4 Nov 2026 and 5 Nov 2026.
- Fill rates
- Of 18 rows: stage 8, sector 9, fund size 17, website 9. In the paid file: named decision-makers on 12 rows, firm email on 4, LinkedIn page on 8, check size on 0.
- Corrections
- Email [email protected] or use the update form. We act within 5 working days.
Questions
How many VC firms are in Missouri?
We list 18 as of November 2026. 6 of the 18 have a fund filing or a dated deal in the last 12 months. By type: VC firm (17) and Corporate VC (1).
Which cities in Missouri have the most VC firms?
St. Louis (10), Kansas City (5) and Clayton (1).
Which Missouri VC funds filed with the SEC in the last 12 months?
5 of the 18 have a fund filing dated in the last 12 months. The most recent on this list are Flyover Capital (Oct 2026), Cultivation Capital (Sep 2026) and Redbud VC (Sep 2026).
What stages do venture capital firms in Missouri back?
Of the 8 with a stage on file, seed (5), pre-seed (3) and Series A (3). A firm can back more than one stage, and 10 rows have no stage on file yet.
Where does the data on venture capital firms in Missouri come from and how often is it updated?
All 18 rows have an SEC filing on file (Form D or Form ADV). Filing date and fund size come from the filing. Stage, sector and check size are our research. Rows on this list were last checked on 5 Nov 2026 at the latest. The whole file is re-verified twice a year.
Can I download the list of venture capital firms in Missouri as a spreadsheet?
Yes. The file holds all 18 rows in Excel and CSV, with 59 named decision-makers and 4 firm emails, for $49 one-time. 10 rows are free on this page.
Broader lists
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