148 pre-seed biotech investors
We list 148 pre-seed biotech investors as of November 2026: 81 have an SEC filing on file and 67 were checked on the firm's own website or an official register, and the list was last checked on 7 Nov 2026. The states with the most are California (34), Massachusetts (13) and Texas (7).
Top 5 pre-seed biotech investors, ranked by recent fund activity
Among firms with a published profile and a dated fund or deal in the last 24 months. The rule: Activity score out of 100: recency of the latest fund filing or dated deal (35: full marks within 3 months, then stepping down at 6, 12 and 24 months), share of the observed portfolio in this sector (25; half of that when the sector is stated only), stage focus (15: all of it when pre-seed is the only stage the firm states, split evenly when it states more), size of the fund on file on a log scale (15) and completeness of the public record (10). Stage focus is our research, not an SEC figure. It is a measure of activity and fit, not of quality or returns. The same rule orders the whole list; it is repeated in the method box.
ARCH Venture Partners
Type: VC firm · HQ: Chicago, IL · Stages: Pre-seed, Seed · Focus: Biotech, Healthtech, Deep Tech · Latest activity: New fund, Aug 2026 · Fund size on file: $3.0B (SEC Form D, 2024)
Latest fund filing dated Aug 2026; $3.0B fund on file (SEC Form D, 2024); 81% of its observed portfolio is biotech and life sciences; backs pre-seed, seed; 8 named decision-makers on file.
First In Ventures
Type: VC firm · HQ: Hobe Sound, FL · Stages: Pre-seed, Seed · Focus: Biotech, Healthtech, AI, Climate Tech · Latest activity: New fund, Sep 2026 · Fund size on file: $22M (SEC Form D, 2026)
Latest fund filing dated Sep 2026; $22M fund on file (SEC Form D, 2026); 69% of its observed portfolio is biotech and life sciences; backs pre-seed, seed; 5 named decision-makers on file.
Transpose Platform
Type: VC firm · HQ: Houston, TX · Stages: Pre-seed · Focus: Biotech, AI, Generalist · Latest activity: New fund, Sep 2026 · Fund size on file: $500M (SEC Form D, 2026)
Latest fund filing dated Sep 2026; $500M fund on file (SEC Form D, 2026); states biotech and life sciences as a focus; backs pre-seed; 8 named decision-makers on file.
SOSV
Type: VC firm · HQ: United States · Stages: Pre-seed · Focus: Biotech, Deep Tech, Climate Tech, Healthtech · Latest activity: Portfolio news, Nov 2026 · Fund size on file: $131M (SEC Form D, 2022)
Portfolio news dated Nov 2026; $131M fund on file (SEC Form D, 2022); states biotech and life sciences as a focus; backs pre-seed; 8 named decision-makers on file.
Thirdrockventures
Type: VC firm · HQ: Boston, MA · Stages: Pre-seed, Seed · Focus: Biotech, Healthtech, Medtech · Latest activity: New fund, Jun 2026 · Fund size on file: $1.1B (SEC Form D, 2022)
Latest fund filing dated Jun 2026; $1.1B fund on file (SEC Form D, 2022); 94% of its observed portfolio is biotech and life sciences; backs pre-seed, seed; 8 named decision-makers on file.
First 25 of 148 pre-seed biotech investors
| Investor | Type | HQ | Stagesour research | Focusour research | Latest fund or deal | Fund sizeas filed or stated | Checked | Contacts |
|---|---|---|---|---|---|---|---|---|
| ARCH Venture Partners | VC firm | Chicago, IL | Pre-seed, Seed | Biotech, Healthtech, Deep Tech | New fund, Aug 2026 | $3.0B (SEC Form D, 2024) | 4 Nov 2026 | 8 names · Unlock |
| First In Ventures | VC firm | Hobe Sound, FL | Pre-seed, Seed | Biotech, Healthtech, AI, Climate Tech | New fund, Sep 2026 | $22M (SEC Form D, 2026) | 4 Nov 2026 | 5 names, firm email · Unlock |
| Transpose Platform | VC firm | Houston, TX | Pre-seed | Biotech, AI, Generalist | New fund, Sep 2026 | $500M (SEC Form D, 2026) | 4 Nov 2026 | 8 names · Unlock |
| SOSV | VC firm | United States | Pre-seed | Biotech, Deep Tech, Climate Tech, Healthtech | Portfolio news, Nov 2026 | $131M (SEC Form D, 2022) | 4 Nov 2026 | 8 names · Unlock |
| Thirdrockventures | VC firm | Boston, MA | Pre-seed, Seed | Biotech, Healthtech, Medtech | New fund, Jun 2026 | $1.1B (SEC Form D, 2022) | 4 Nov 2026 | 8 names · Unlock |
| Column Group | VC firm | San Francisco, CA | Pre-seed | Biotech, Healthtech | New deal, Jan 2026 | $600M (SEC Form D, 2022) | 4 Nov 2026 | 8 names, firm email · Unlock |
| Atlas Venture | VC firm | Cambridge, MA | Pre-seed | Biotech, Healthtech | New deal, Jan 2026 | $450M (SEC Form D, 2022) | 4 Nov 2026 | 5 names · Unlock |
| Mission BioCapital | VC firm | Cambridge, MA | Pre-seed | Biotech, Healthtech, Medtech | New fund, Apr 2026 | $192M (SEC Form D, 2021) | 4 Nov 2026 | 8 names, firm email · Unlock |
| LYVA Labs | Government or university fund | Liverpool, United Kingdom | Pre-seed | Biotech, AI, Healthtech, Climate Tech | Portfolio news, Oct 2026 | £7M (own site) | 4 Nov 2026 | 8 names, firm email · Unlock |
| NLC Health Ventures | VC firm | Amsterdam, Netherlands | Pre-seed, Seed | Biotech, Healthtech, Medtech | New fund, Sep 2026 | €300M (own site) | 7 Nov 2026 | 4 names, firm email · Unlock |
| Start Codon | Accelerator | Cambridge, United Kingdom | Pre-seed, Seed | Biotech, Healthtech, AI | Portfolio news, Nov 2026 | 4 Nov 2026 | 4 names, firm email · Unlock | |
| Zinc | Accelerator | London, United Kingdom | Pre-seed | Biotech, Healthtech, AI, Climate Tech | Portfolio news, Jul 2026 | 4 Nov 2026 | 8 names, firm email · Unlock | |
| Hyve Ventures | VC firm | Austin, TX | Pre-seed | Biotech, Consumer, Healthtech, Logistics | New fund, Nov 2026 | $6M (SEC Form D, 2025) | 4 Nov 2026 | 1 name · Unlock |
| Monograph Capital | VC firm | Fort Worth, TX | Pre-seed | Biotech, Healthtech | New deal, Jun 2026 | $326M (SEC Form ADV) | 5 Nov 2026 | 8 names, firm email · Unlock |
| XISTA Science Ventures | VC firm | Klosterneuburg, Austria | Pre-seed, Seed | Biotech, Deep Tech, AI, Industrial Tech | Portfolio news, Oct 2026 | €96M (own site) | 7 Nov 2026 | 4 names, firm email · Unlock |
| Claris Ventures | VC firm | Turin, Italy | Pre-seed, Seed, Series A | Biotech, Healthtech | New fund, Oct 2026 | €190M (own site) | 7 Nov 2026 | 4 names, firm email · Unlock |
| Outlier Ventures | VC firm | United Kingdom | Pre-seed, Seed, Series A, Growth | Biotech, AI, Robotics, Fintech | New deal, Oct 2026 | $500M (own site) | 4 Nov 2026 | LinkedIn page · Unlock |
| Madrona | VC firm | Seattle, WA | Pre-seed, Seed, Series A, Series B, Growth | Biotech, AI, Consumer, Deep Tech | New deal, Oct 2026 | $490M (SEC Form D, 2025) | 5 Nov 2026 | 8 names · Unlock |
| Cure Ventures | VC firm | Boston, MA | Pre-seed, Seed | Biotech, Healthtech | New fund, Dec 2025 | $350M (SEC Form D, 2021) | 4 Nov 2026 | 8 names, firm email · Unlock |
| Even One Ventures | VC firm | San Francisco, CA | Pre-seed | Biotech, Healthtech, Medtech | New fund, Feb 2026 | $20M (SEC Form D, 2026) | 4 Nov 2026 | 8 names · Unlock |
| Bison Ventures | VC firm | San Francisco, CA | Pre-seed, Seed, Series A, Series B | Biotech, AI, Healthtech, Energy | New fund, Oct 2026 | $160M (SEC Form D, 2025) | 4 Nov 2026 | 2 names, firm email · Unlock |
| Avalon BioVentures | VC firm | La Jolla, CA | Pre-seed | Biotech, Healthtech, Space | Portfolio news, Nov 2024 | $200M (SEC Form D, 2021) | 5 Nov 2026 | 8 names, firm email · Unlock |
| True Ventures | VC firm | Palo Alto, CA | Pre-seed, Seed | Biotech, AI, Fintech, Deep Tech | New fund, Sep 2026 | $800M (SEC Form D, 2022) | 4 Nov 2026 | 8 names · Unlock |
| Kapor Capital | VC firm | Oakland, CA | Pre-seed, Seed, Series A | Biotech, Edtech, Fintech, Healthtech | New deal, Jun 2026 | $125M (SEC Form D, 2021) | 5 Nov 2026 | 5 names · Unlock |
| Voltage Ventures | VC firm | Portland, ME | Pre-seed | Biotech, Healthtech, Medtech | New fund, Jul 2026 | $18M (SEC Form D, 2026) | 4 Nov 2026 | 4 names · Unlock |
You are seeing 25 of 148. The full list adds 123 more investors and 747 named decision-makers.
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How these 148 break down
By region
| Region | On this list | Share |
|---|---|---|
| United States | 81 | 55% |
| United Kingdom | 41 | 28% |
| Europe | 26 | 18% |
By US state
| US state | On this list | Share |
|---|---|---|
| California | 34 | 23% |
| Massachusetts | 13 | 9% |
| Texas | 7 | 5% |
| New York | 6 | 4% |
| Florida | 3 | 2% |
| Washington | 2 | 1% |
| New Jersey | 2 | 1% |
| Oregon | 2 | 1% |
By European country
| European country | On this list | Share |
|---|---|---|
| Spain | 5 | 3% |
| France | 5 | 3% |
| Germany | 4 | 3% |
| Netherlands | 3 | 2% |
| Austria | 2 | 1% |
| Italy | 2 | 1% |
By type
| Type | On this list | Share |
|---|---|---|
| VC firm | 121 | 82% |
| Government or university fund | 11 | 7% |
| Accelerator | 6 | 4% |
| SEIS/EIS fund | 5 | 3% |
| Angel network | 3 | 2% |
Method and limits
- Source
- 81 of the 148 rows carry an SEC filing (Form D or Form ADV). All 148 have a website we checked. Filing date and fund size are SEC data where a filing exists. Stage, sector and check size are our research.
- Inclusion rule
- Organizations that back startups. Individuals, buyout funds and firms we found to be inactive are left out. Sector: the firm states biotech and life sciences as a focus on its own site, or we observed it in the firm's portfolio. Stage: the firm states that it invests at pre-seed.
- Order
- Firms with a published profile come first. Activity score out of 100: recency of the latest fund filing or dated deal (35: full marks within 3 months, then stepping down at 6, 12 and 24 months), share of the observed portfolio in this sector (25; half of that when the sector is stated only), stage focus (15: all of it when pre-seed is the only stage the firm states, split evenly when it states more), size of the fund on file on a log scale (15) and completeness of the public record (10). Stage focus is our research, not an SEC figure. It is a measure of activity and fit, not of quality or returns.
- Last refreshed
- November 2026. Rows on this list were checked between 4 Nov 2026 and 7 Nov 2026.
- Fill rates
- Of 148 rows: stage 148, sector 148, fund size 95, website 148. In the paid file: named decision-makers on 138 rows, firm email on 76, LinkedIn page on 105, check size on 43.
- Corrections
- Email [email protected] or use the update form. We act within 5 working days.
Questions
How many pre-seed biotech investors are there?
We list 148 as of November 2026. 80 of the 148 have a fund filing or a dated deal in the last 12 months.
Which pre-seed biotech investors raised a new fund in the last 12 months?
43 of the 148 have a fund filing dated in the last 12 months. The most recent on this list are Hyve Ventures (Nov 2026), Draper Associates (Oct 2026) and Pear Ventures (Oct 2026).
What is the typical fund size of pre-seed biotech investors?
The median fund size on file for this list is $73M, across the 58 firms with a size on an SEC Form D. The fund on file is each firm's main fund, which is not always its newest. The other 90 do not disclose a size there.
How do I contact pre-seed biotech investors?
The paid file holds 747 named decision-makers across 138 of these 148 and a firm email for 76. We publish the address a firm lists itself, never a personal email. Each free row links to a profile with the firm's website.
Where does the data on pre-seed biotech investors come from?
81 of the 148 rows have an SEC filing on file (Form D or Form ADV) and 67 were checked on the firm's own website or an official register. Filing date and fund size come from the filing. Stage, sector and check size are our research. Rows on this list were last checked on 7 Nov 2026 at the latest. The whole file is re-verified twice a year.
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